Prof. Liberale's research interests are focused on developing and applying label-free chemical imaging techniques based on vibrational spectroscopy (Infrared and Raman micro-spectroscopy) and multi-photon processes (Coherent Raman Microscopy, SHG). One of the main aims of this research activity is to unveil specific bio-chemical signatures of cancer stem cells, with a particular focus on understanding the dysregulation of their lipid metabolism.

He is also interested on using high-resolution 3D printing based on Direct Laser Writing for the fabrication of novel micro-optics, towards the miniaturization of complex optical systems, and of smart micro-/nano-structures to be used as a probe in nanoscale imaging. This research activity takes advantage from an integrated approach that combines design, micro/nanofabrication and optical techniques.​​