Siarhei Laptenok

Research Group Staff

Research Scientist

Current

Social Profile:

Biography

​Label-free based on vibrational spectroscopy and multi-photon methods (coherent Raman microscopy, SHG, THG) and fluorescent imaging methods applied to biology and medicine. Ultrafast dynamics of complex condensed phase systems and interfaces. Role of the protein dynamics in its functions. Development and application of ultrafast methods in spectroscopy and microscopy (IR/visible femtosecond pump-probe spectroscopy, time-resolved fluorescence spectroscopy, Fluorescence Lifetime Imaging Microscopy)​. Development of methods and applications for Global and Target analysis of time-resolved spectroscopy and microscopy data. Developing an application called Glotaran: glotaran.org

Selected Publications

  • Snellenburg, J. J., Laptenok, S. P., DeSa, R. J., Naumov, P., & Solntsev, K. M. Excited-State Dynamics of Oxyluciferin in Firefly Luciferase. J Am Chem Soc., jacs.6b05078. http://doi.org/10.1021/jacs.6b05078 (2016).
  • Laptenok, S. P., Lukacs, A., Gil, A., Brust, R., Sazanovich, I. V., Greetham, G. M. , Tonge P. J, & Meech, S. R. Complete Proton Transfer Cycle in GFP and Its T203V and S205V Mutants. Angewandte Chemie, 127(32), 9435–9439. (2015)
  • Laptenok, S. P., Bouzhir-Sima, L., Lambry, J.-C., Myllykallio, H., Liebl, U., & Vos, M. H. Ultrafast real-time visualization of active site flexibility of flavoenzyme thymidylate synthase ThyX. Proc Natl Acad Sci U S A 110, 8924–9.(2013)
  • Solntsev, K. M., Laptenok, S. P., Naumov, P.: Photoinduced dynamics of oxyluciferin analogues: Unusual enol “super”photoacidity and evidence for keto-enol isomerization J Am Chem Soc, 134(40), 16452-16455 (2012).
  • Snellenburg J. J, Laptenok S.P., Seger R., Mullen K.M., van Stokkum I. H. M.,  Glotaran: A Java-Based Graphical User Interface for the R Package TIMP  J Stat Soft, 49(3)  1-23, (2012)

Education

  • ​Ph.D. Laboratories of Biochemistry and Biophysics, Wageningen University and Research Center, 2009
  • M.S. Department of System Analysis, Faculty of Radio Physics and Electronics Belarusian State University, 2004
  • ​​B.S. Faculty of Radio Physics and Electronics Belarusian State University, 2003

Professional Profile

  • June 2016: Postdoctoral fellow in a King Abdullah University of Science and Technology
  • April 2013 - June 2016: Senior Post Doctoral Research Associate in School of Chemistry at the University of East Anglia, Norwich, UK.
  • April 2010 - April 2013: Postdoctoral researcher in the Laboratory for Optics and Biosciences at the Ecole Polytechnique, Palaiseau, France.
  • ​February 2009 - April 2010: postdoctoral researcher in the Biophysics group at the Faculty of Exact Sciences, of the Vrije Universiteit, Amsterdam, The Netherlands.​

Research Interests Keywords

Optics BioPhotonics Live Cell Imaging Global Analysis Infrared Spectroscopy Time Resolved Spectroscopy Stimulated Raman Scattering Fluorescence Microscopy